Coxsackie ( kuuk-SAK-ee) is a town in Greene County, New York, United States. The population was 8,918 at the 2010 census. The name of the town is said to be derived from a Native American term, but it has various translations (“owl’s hoot” is locally common). Within the area governed as a town, there is also a village called Coxsackie. The town is in the northeast part of the county. The town of Coxsackie is notable for being the namesake of the Coxsackievirus, which was first isolated in this town. The settlement of Coxsackie began in the seventeenth century, approximately 1652, as part of the development of New Netherland. The government of the area became established as a district in 1772, and Coxsackie was founded in 1788 with a town form of government.
Part of Coxsackie was lost when the town of Durham was formed in 1790. Further land was lost in the formation of the newer towns of Cairo and Greenville (1803), New Baltimore (1811), and Athens (1815). One of the first settlers in Coxsackie was Pieter Bronck, of the same family for which the Bronx is named. In 1663, he built the Pieter Bronck House in West Coxsackie, which is open as a museum. The nearby family burial ground includes a separate plot with marked graves for slaves of the family.In 1900, the combined population of the town and village was 2,994. According to the United States Census Bureau, the town has a total area of 38.4 square miles (99.4 km2), of which 36.9 square miles (95.6 km2) is land and 1.5 square miles (3.8 km2, or 3.86%) is water.
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