Sikeston is a city located both in southern Scott County and northern New Madrid County, in the state of Missouri, United States. It is situated just north of the “Missouri Bootheel“, although many locals consider Sikeston a part of it. By way of Interstate 55, Interstate 57, and U.S. Route 60, Sikeston is close to the halfway point between St. Louis and Memphis and three hours from Nashville. The city is named after John Sikes, who founded it in 1860. It is the principal city of the Sikeston Micropolitan Statistical Area, which consists of all of Scott County, and has a total population of 41,143. As of the 2010 census, the city population was 16,318, making it the fourth-most populous city in Missouri’s 8th Congressional district (map) behind Cape Girardeau, Rolla, and Poplar Bluff and just ahead of Farmington.
Before the 2010 census, it had been the second-most populous city in the district. The first explorers and settlers came to a region of cypress swamps and forested prairies. At the beginning of the 20th century, the Little River Drainage District was formed to reclaim the land. This was the world’s largest drainage project, moving more earth than completed during the construction of the Panama Canal.In 1541, Spanish explorer Hernando de Soto may have stood upon the Sikeston Ridge, although some historical references dispute this, believing that he traveled further south than Sikeston.
information provided by wikipedia.org